Category: Uncategorized

CGHS related info

CGHS empanelled hospitals in NCR 

PDF | Google spreadsheet

Book appointment with CGHS doctor online

Instructions: here.

Go to this.

Medicine reimbursement rules

https://cghs.gov.in/index1.php?page=1&ipp=100&lang=1&level=2&sublinkid=5821&lid=3751

CIRCULARS REGARDING MEDICINES FROM LOCAL CHEMIST TILL 31 OCTOBER 2021

Circular dated 15 April 2021

Circular dated 10 August 2021

CGHS Gurgaon

https://cghs.gov.in/showfile.php?lid=3997

CGHS officials

Manoj Jain: https://cghs.gov.in/WriteReadData/l892s/CGHS%20Directorate%20Contact%20Details5.pdf

 

Continue Reading

Vaccine choices in India

Astra Zeneca (Covidshield)
Europe stopped the Astra Zeneca vaccine (which comes here as Covishield) for people under the age of 55 years because maximum harm was seen in this younger group. Gap between two doses of the vaccine is three months for Covishield.

Johnson and Johnson vaccine has also been related with the clotting side effect, although the incidence is said to be low in both cases. This one dose vaccine is coming in November.

Bharat Biotechs Covaxin. With that clotting is not much reported. That can be considered. Gap between two doses of the vaccine is 4 weeks for Covaxin 

The Russian vaccine Sputnik is another alternative. Gap between two doses of the vaccine is 3 weeks for Sputnik.

For persons with DVT
The vaccine is given Intramuscular and in a person taking blood thinners there is a small risk of formation of local hematoma or blood leakage and collection. To prevent that perhaps same precaution of missing the prior day evening dose can be applied.

Continue Reading
Continue Reading

Treating neuroendocrine cancer/tumour

SPECIALISED WEBSITES

INCA: International Neuroendocrine Cancer Alliance

Living with NET

NET society of India

Facebook page

This is a good summary: https://www.cancercenter.com/cancer-types/neuroendocrine-tumors/treatments

ICMR’s  CONSENSUS TREATMENT

Click to access Consensus_2.pdf

WHY INSUFFICIENT RESEARCH

“this orphan group of tumors which does not hold much interest to the pharmaceutical companies.” [Source]

BROAD TREATMENTS 

Depending on the type of NET, medications that may be used include:

  • Somatostatin analogs
  • Chemotherapy
  • Targeted therapy
  • Immunotherapy
  • Peptide receptor radionuclide therapy (PRRT)  [Source]

Octreotide LAR

This is a form of somatostatin treatment: From somatostatin to octreotide LAR: evolution of a somatostatin analogue

“Octreotide is a potent synthetic somatostatin analogue that has become the mainstay of medical therapy for tumor control in neuroendocrine disorders. The multiple effects of octreotide throughout the body, combined with its established safety profile, make it an appealing and reliable option for clinicians. ”

“the antiproliferative effect of octreotide LAR in patients with well-differentiated metastatic GEP-NETs of the midgut” – but this is POORLY differentiated.

“Octreotide was among the first biotherapeutic agents used in the management of GEP-NETs and continues to be a mainstay of therapy today, although it is rarely curative”

“In response to results from the PROMID study, guidelines from the National Comprehensive Cancer Network (NCCN) have been updated to recommend octreotide LAR 20–30 mg as a management option in patients with recurrent or unresectable metastatic carcinoid tumors originating from any primary site of disease (small bowel, colon, rectum, appendix, lung, thymus, stomach) irrespective of functional status, symptomatology and progression status” [While there might be an origin in the colon/rectum, there is also a possible link with the prostate]

SIDE EFFECTS OF CHEMOTHERAPY

 

 

Continue Reading

Chemotherapy for large cell neuroendocrine carcinoma

For NET: 

etoposide and cisplatin/ carboplatin (at 50% for 2 days at a time)

SIDE EFFECTS

Comparing the adverse effects of platinum in combination with etoposide or irinotecan in previously untreated small-cell lung cancer patients with extensive disease: A network meta-analyses

See this PDF file (taken from here)

For lung

Chemotherapy medications commonly used to treat LCLC include Altima (pemetrexed) and Platinol (cisplatin) [Source]

 

Chemotherapy causes death in more than 25% of cancer patients

Continue Reading