Nexium causes kidney disease and early death. What are the alternatives?

It has now been conclusively proven that Nexium and other proton pump inhibitors (e.g. Prilosec) dramatically increase the following health risks:

  1. kidney failure:  “It is very reasonable to assume that PPIs themselves can cause chronic kidney disease,” said Dr. Pradeep Arora, a nephrologist and associate professor at the SUNY Buffalo School of Medicine and Biomedical Science in Buffalo, N.Y. [Source]. Further: “People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers, said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore. The study was published Jan. 11 in JAMA Internal Medicine.” [Source]
  2. premature death: People taking a PPI also had nearly twice the risk of dying prematurely [Source]
  3.  bone fractures and infections of C. difficile and pneumonia: “they’ve been tied to other health problems such as bone fractures and infections of C. difficile and pneumonia” [Source] Clostridium difficile bacteria can cause life-threatening colitis. people taking proton pump inhibitors were almost three times more likely to have a C-difficile infection than non-users. he risk of pneumonia was 89% higher for those using proton pump inhibitors and 63% higher for those using H2-receptor antagonists.[Source].
  4. liver toxicity: [Source]
  5. All kinds of other problems: “PPI users were more likely to have health problems, such as obesity, high blood pressure and heart problems” [Source]
  6. Depletion of magnesium: “The medications can cause magnesium levels to decline in the body, and a lack of this important mineral could damage the kidneys” [Source]
  7. Depletion of calcium: Due to reduced acid, it becomes harder to absorb calcium.

See also: CNN: Popular medications linked to higher risk of kidney failure


twice-daily use was associated with a 46 percent increased risk of chronic kidney disease, versus a 15 percent increased risk in those taking one daily dose. [Source]

Nexium & Prilosec Lawsuit

There is a lawsuit going on:


This article argues that prilosec/omeprazole should be taken, but these are effectively the same drug. That’s no solution.

Natural alternatives: at Livestrong |


1) Take as little of Nexium as possible.

If you do have to take Nexium, take magnesium supplements.

2) Try H2 blockers: Pepcid, Tagamet or Zantac.

“These types of studies, these big data studies, can sometimes suggest a signal that something’s going on, but I don’t know if they prove it,” DeVault said. Grams said the study authors tried to address that concern by comparing PPI users to people using another heartburn medication called H2 blockers. Both patient groups tended to be equally unhealthy, but PPI users had a 39 percent higher risk of chronic kidney disease, the researchers said. [Source]

“Doctors also might opt to prescribe an H2 blocker like Pepcid, Tagamet or Zantac. “To me, this is a cheaper, safer alternative that might work as well with some patients,” Swaminath said.” [Source]


In 2000, the histamine H-2 receptor blocker, Propulsid, was taken off the market due to associated cardiac deaths. [Source] (I was initially prescribed Propulsid for many years)

Both proton pump inhibitors and the histamine H-2 blocking drugs can raise the risk of hip fractures by 44% if taken for longer than a year because, when you block acid production, you make it more difficult for the body to absorb calcium. [Source]

3) Try Dexsilant

See this:


“medications do not fix anything, they allow the underlying problem to continue uncorrected and actually accelerate” [Source: see note by Jodi-Hummingbird here]

1) The usual advice

Give up: coffee, cigarettes, carbonated beverages, food additives, artificial foods

Test for: candida, HPylori, parasites, food allergies, bacteria, gluten sensitivity, lactose sensitivty, leaky gut syndrome

Try: chewing more times, raising head of bed, smaller meals, digestive enzymes, DGL, aloe, wait 3 hours before lying down, probiotics, food elimination diet [Source]

2) Try apple cider vinegar

– for a short period of time.

3) Try to wean off Nexium

This youtube video provides some thoughts.

4) eat frequent small meals throughout the day instead of the usual three large meals.

5) vegetable juices include carrot, spinach, beet, cucumber, parsley, celery, cabbage and potato

6) Reduce carbohydrates

This was very persuasive (from around 4.5 minutes)

Ini particular, white flour seems to be a culprit [See review by Frog Man here] – bread?


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One thought on “Nexium causes kidney disease and early death. What are the alternatives?
  1. Amy Aadland

    I agree with your points, use of Nexium drug is the cause of the kidney disease. We can use natural treatment as the alternative to drugs. My uncle also used this & get well in very fewer times. He regularly used natural alternative for Nexium as “Acidgone®” . Now he is feeling better than before. Hope it will help others.


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